Objective: In this study, we report a patient who developed lumbar epidural hematoma after trans-sacral epiduroscopic laser decompression (SELD). Background: SELD is a nonoperative minimally invasive spinal procedure, in which a herniated lumbar disk can be ablated by laser. Because of the rich epidural venous plexus, the procedure might have a risk of epidural hematoma. Materials and methods: A 57-year-old woman underwent the SELD procedure for the treatment of lower back and right buttock pain due to disk protrusion at L5-S1. One day after the procedure, complete motor weakness was observed in the right leg. Results: Lumbar magnetic resonance imaging revealed epidural hematoma at the L1-L5 levels, compressing the thecal sac. Using a posterior approach, decompressive subtotal laminectomy on L1 and total laminectomy on L2-L5 with evacuation of the hematoma were performed. Two months postoperatively, near complete resolution of the motor weakness in the right leg was observed. Conclusions: Clinicians should keep in mind the likelihood of epidural hematoma after SELD.