Introduction The LLIF was a revolutionary approach devised by Luiz Pimenta that allowed the surgeon to access the lumbar spine through the major psoas muscle. Although the traditional LLIF had enabled enormous advances, the technique has its drawbacks. A new concept to perform the traditional LLIF was proposed, with the patient being prone to decubitus and slightly extended legs. The study aims to analyze the early outcomes of patients who had undergone the PTP for degenerative spine pathologies, including the L4/5 level Methods Multicentric, retrospective, non-randomized, non-comparative, observational study. Only were included in the study, participants that received PTP in L4/5, no more than three levels of intersomatics, fixation no further than S1. The primary outcomes were the onset of new neurologic deficits and postoperative complications. Also, surgery details, such as blood loss and surgery duration, were measured. The neurological deficits were accessed at the postoperative visit that ranged from 7 to 14 days after the surgery. Results Twenty-seven patients fulfilled the inclusion and exclusion criteria, with the majority receiving PTP only in L4/5 (66,6%). The mean surgery time was 182, with 29min of mean Transpsoas time. Of the patients, only one presented the onset of a motor deficit, while three patients presented a new sensory deficit. Five complications occurred, none intraoperative and five postoperative, with only one directly correlated with the access. Conclusion The Prone Transpsoas is safe and feasible for approaching the L4/5 disc, presenting with a low rate of complication and new neurological deficits onset.