Objective:

To compare 1) postoperative milligram equivalents (MME) prescriptions for opioid-naïve patients undergoing single-level transforaminal lumbar interbody fusion (TLIF) versus posterolateral lumbar decompression and fusion (PLF) and 2) total postoperative MME prescribed based on operative duration.

Methods:

Patients undergoing single-level TLIF or PLF from September 2017 to June 2020 were identified from a single institution. Patients were first grouped based on procedure type (TLIF or PLF), and subsequently regrouped based on median operative duration. Statistical tests compared patient demographics and opioid prescription data between groups. Multivariate regressions were performed to control for demographics, operative time, and procedure type.

Results:

Of 345 patients undergoing a single level PLF or TLIF, 174 (50.4%) were opioid-naïve. A total of 101 opioid-naïve patients (58.0%) underwent PLF and 73 (42.0%) underwent TLIF. TLIF patients received more opioid prescriptions (1.99 vs. 1.26, p<0.001) and total morphine milligram equivalents (MME) (91.2 vs. 66.8, p=0.002). After regrouping patients based on operative duration, independent of procedure type, there were no differences in postoperative opioid prescriptions, and the Spearman's rank correlation coefficient between total MME and operative duration was r=0.014. Multivariate analysis identified TLIF as an independent predictor of increased postoperative opioid prescriptions (β=0.64, p<0.001), prescribers (β=0.49, p=0.003), and MME (β=24.4, p=0.030).

Conclusion:

Opioid-naïve patients undergoing single-level TLIF receive a greater number of postoperative opioids than patients undergoing single-level PLF, and TLIF was an independent predictor of increased postoperative opioid prescribers, prescribers, and MME. There were no differences in postoperative opioid prescriptions when assessing patients based on operative duration.