Denosumab salvage therapy in an 11-year-old boy with locally recurrent unresectable giant cell tumor of the lumbar spine after surgery

March 6, 2023

. 2023 Feb 23;69(3):101427.

doi: 10.1016/j.neuchi.2023.101427.

Online ahead of print.

Affiliations

Free article

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Y Luo et al.

Neurochirurgie.

2023.

Free article

. 2023 Feb 23;69(3):101427.

doi: 10.1016/j.neuchi.2023.101427.

Online ahead of print.

Affiliations

¹ Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, No. 37 Guo Xue Road, Chengdu 610041, China.
² Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, No. 37 Guo Xue Road, Chengdu 610041, China. Electronic address: [email protected].

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Abstract

Giant cell tumors (GCTs) of the bone are locally aggressive primary bone tumors with a benign character. Spinal involvement is rare which accounts for approximately 5% of all primary bone tumors and it is quite rare in the lumbar spine. An 11-year-old boy patient presented with pain of low back and bilateral low extremities. Lumbar CT and MRI revealed a lytic lesion of the L4 vertebra corpus. The patient earned remarkable and timely recovery with 2 surgical interventions and the use of denosumab. Surgical resection for GCTs is still preferable as the initial treatment, denosumab should be utilized after tumor resection whether based on the purpose of prevention or treatment of tumor recurrence.

Keywords:

Case report; Denosumab; Fusion; Giant cell tumor (GCT); Spine.

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