Minimally Invasive Spinal Stabilization with Denosumab before Total Spondylectomy for a Collapsing Lower Lumbar Spinal Giant Cell Tumor

March 3, 2021

Case Reports

doi: 10.18926/AMO/61442.

Affiliations

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Case Reports

Keitaro Minato et al.

Acta Med Okayama.

2021 Feb.

Abstract

A 21-year-old man consulted our hospital for treatment of a spinal giant cell tumor (GCT) of Enneking stage III. Lower lumbar-spine tumors and severe spinal canal stenosis are associated with high risk for surgical mor-bidity. Stability was temporarily secured with a percutaneous pedicle screw fixation in combination with deno-sumab, which shrank the tumor. Total en bloc spondylectomy was then performed 6 months after initiation of denosumab, and the patient was followed for 3 years. There was no local recurrence, and bony fusion was obtained. Minimally invasive surgery and denosumab allowed safer and easier treatment of a collapsing lower lumbar extra-compartmental GCT.

Keywords:

denosumab; giant cell tumor; spinal stabilization; spondylectomy.

Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

References

1. Dorfman DH and Czerniak B: Bone tumor. Elsevier, Philadelphia (1998) pp 692-759.
1. Chakarun CJ, Forrester DM, Gottsegen CJ, Patel DB, White EA and Matcuk GR Jr: Giant cell tumor of bone: review, mimics, and new developments in treatment. Radiographics (2013) 33: 197-211.
1. Campanacci M: Tumor of the spine: Giant cell tumors of the spine, WB Saunders, Philadelphia (1990).
1. Boriani S, Weinstein JN and Biagini R: Primary bone tumors of the spine. Terminology and surgical staging. Spine (1997) 22: 1036-1044.
1. Tomita K, Kawahara N, Murakami H and Demura S: Total en bloc spondylectomy for spinal tumors: improvement of the technique and its associated basic background. J Orthop Sci (2006) 11: 3-12.