Risk factors for cage retropulsion after lumbar interbody fusion: A systematic review and meta-analysis.


Although many risk factors for cage retropulsion (CR) following lumbar interbody fusion (LIF) have been described in the literature, they still remain controversial. The purpose of this study is to investigate the risk factors for CR after LIF.


The literature was searched in Pubmed, Cochrane library and Embase from October 2000 to October 2018. The keywords and combinations used in the search included: LIF, cage, retropulsion, posterior migration and risk factors. Only studies with sufficient data to calculate odds ratio (OR) for CR were included. OR and 95% confidence interval (Cl) were calculated for outcomes via RevMan5.3 and SPSS 22.0.


A total of 10 studies were included in this study. Twelve risk factors were assessed by analyzing 4467 patients. The pooled results indicated that pear-shaped disc and straight cage were significant risk factors for CR. However, factors that had no significant relation with CR were preoperative diagnosis (disc herniation, spinal stenosis and spondylolisthesis), gender, surgical segments (from L2 to S1), multilevel fusion and unilateral pedicle screws fixation (UPSF).


According to current evidence, pear-shaped disc and straight cage are significant risk factors for CR. However, preoperative diagnosis, gender, multilevel fusion, surgical segments and UPSF are not the risk factors associated with CR. A revision surgery is needed when neurologic symptoms happened after CR. The conclusion should be consulted cautiously due to the limited number of included studies. Therefore, larger scale studies are still needed to investigate the risk factors for CR.

Share on facebook
Share on twitter
Share on linkedin
Share on vk
Share on pinterest
Close Menu